TAMs have been identified as key contributors to the advancement of HCC by aiding its spread and encouraging EMT [71], related mechanisms include hypoxia-inducible factor 1-alpha (HIF-1α)/IL-1β/TLR4 [72] and Janus kinase 2 (JAK2)/STAT3/Snail [73] pathways. This evidence concerns the gene STAT3 and hepatocellular carcinoma.