Furthermore, the diagnostic effectiveness of YBX1, MED8, and KPNA2 in the NASH cohort was evaluated using ROC analysis, revealing their exceptional performance with area under the curve (AUC) values of 0.839, 0.875, and 0.946, respectively (Fig. 7I). The gene discussed is YBX1; the disease is metabolic dysfunction-associated steatohepatitis.