It is well known that the shielding of toxic hydrophobic regions exposed on the oligomer surface by either polyclonal or monoclonal Abs, extracellular chaperones and even other proteins present in biological fluids such as transthyretin, appears to be an effective method to suppress the toxicity of misfolded Aβ42 oligomers [16, 18, 84, 85], but the high sensitivity and selectivity of DesAb-O and possibly other sdAbs relative to other Abs and chaperones could offer a remarkable potential of these biotechnological tools against AD particularly in its early stages. Here, TTR is linked to Alzheimer disease.