Additionally, to analyze the correlation between METTL3 expression and distant metastasis, we utilized the data independent acquisition-mass spectrometry (DIA-MS) data from a late-stage NSCLC cohort conducted by Lehtiö et al. [24] Comparing the METTL3 expression in biopsy samples from 12 M0 stage patients and 15 M1 stage patients, we discovered that patients with distant metastasis exhibited higher levels of METTL3 compared to those without distant metastasis (Fig. 1G, Table S2). The gene discussed is METTL3; the disease is non-small cell lung carcinoma.