MAPT and Alzheimer disease: Lastly, we demonstrate that the use of antioxidants directly targeting mitochondria is effective at decreasing mitochondrial oxidative stress to basal levels and reverting Aβ plaque-associated dystrophic neurites in these AD mice, supporting the idea that mitochondria-targeted compounds that prevent or minimize mitochondrial dysfunction could hold promise as neuroprotective drugs against AD progression, and could be used in combination with other anti-amyloid beta and/or anti-tau therapies.