Patients who had developed renal progression/death had longer duration of COPD (7.05 years vs. 4.79 years, p = 0.029), higher rates of requiring long-term oxygen therapy (26.2% vs. 7.1%, p = 0.024), lower baseline blood eosinophil count and percentage (233 cells/μL vs. 343 cells/μL and 3.30% vs. 4.43%; p = 0.033 and 0.039 respectively), and lower serum albumin level (26.6 g/L vs. 29.4 g/L, p < 0.001). The gene discussed is ALB; the disease is chronic obstructive pulmonary disease.