There are several mechanisms for worse COVID-19-related outcomes in the male sex: woman have a higher rate of vaccination and seek medical care more often and at early stages of the disease [24], inherent immunological differences (X chromosome has the largest number of genes related to the integrity of immune system) [23], and the higher testosterone levels (which facilitates SARS-CoV-2 entry via angiotensin-converting enzyme 2 expressed on cell surfaces) [25]. The gene discussed is ACE2; the disease is COVID-19.