In NSCLCs, the top 10 mutated genes were EGFR (57%), TP53 (46%), LRP1B (10%), PIK3CA (8%), KRAS (8%), FAT1 (6%), KEAP1 (6%), ATM (5%), CDKN2A (5%), and NF1 (4%) (Fig. S2F) which might play an important role in the biological processes of NSCLC. The gene discussed is PIK3CA; the disease is non-small cell lung carcinoma.