The study reveals novel markers with strong observational relations to lung function such as RSPO4, a signalling molecule that is part of the Wnt signalling pathway [56], the tumor marker ALPPL2 [57], the adipokine chemerin (RARRES2), and SVEP1, a protein that is thought to play a role in inflammation in atherosclerosis [58]. Here, RARRES2 is linked to atherosclerosis.