A correlation matrix analysis of MP load, lung microbiome indicators (top 10 DES, except for MP), host response indicators (the expression of top 10 hub black DEGs), and clinical indicators, including N%, CRP, ALT, LDH, PT, APTT, and D-dimer, indicated the potential interactions among the three core elements of respiratory infection: pathogen, lung microbiome, and host response. Here, CRP is linked to respiratory tract infectious disorder.