Finally, in a solid tumor model of SKOV3 ovarian cancer treated with a single infusion of anti-TROP2-CAR/IL-15 NK cells (CAR-TROP2/IL-15), CAR-NK cells from Opt-Cs resulted in superior antitumor control and survival compared to those from Sub-Cs (Extended Data Fig. 9m–o and Supplementary Fig. 4c). The gene discussed is TACSTD2; the disease is ovarian cancer.