Furthermore, in the drug sensitivity and resistance analysis, we found that the expression of ALYREF and YBX1 was positively correlated with resistance to chemotherapy (fenretinide, melphalan, XL-147, and fludarabine) and positively correlated with sensitivity to chemotherapy (ARRY162) in various cancers, which indeed provides valuable insights for future research on increasing chemotherapy sensitivity and combating chemotherapy resistance. The gene discussed is ALYREF; the disease is cancer.