YBX1 and cancer: Furthermore, in the drug sensitivity and resistance analysis, we found that the expression of ALYREF and YBX1 was positively correlated with resistance to chemotherapy (fenretinide, melphalan, XL-147, and fludarabine) and positively correlated with sensitivity to chemotherapy (ARRY162) in various cancers, which indeed provides valuable insights for future research on increasing chemotherapy sensitivity and combating chemotherapy resistance.