Compared with normal tissues, the expression of BDNF, FOXM1, SALL4, SERPINE1, TRIP6, LIMK1, EEPD1, MYT1, PBK, HMGA2, MAD2L1, and CDC25C was increased, while SYP, GRIN3A, EYA2, NGFR, MAPK10, FHL1, PBX1, STMN2, and IGF1 expression was decreased in COAD (Fig. 1C). This evidence concerns the gene EYA2 and colon adenocarcinoma.