Among them, SYCE2, SYP, BDNF, ALPP, GRIN3A, EYA2, NGFR, FOXM1, SALL4, SERPINE1, TRIP6, MAPK10, LIMK1, EEPD1, FHL1, PBX1, MYT1, PBK, HMGA2, MAD2L1, CDC25C, STMN2, and IGF1 were identified as candidate genes significantly associated with the OS of COAD patients (Fig. 1B). The gene discussed is ALPP; the disease is colon adenocarcinoma.