Since DPYSL5 is known to promote the growth of axons in early nervous system development, and based on our GSEA results showing DPYSL5 overexpression-induced NEPC signature and invasiveness, we investigated whether DPYSL5 overexpression alone can induce neurite-like changes and promote the growth of invadopodia in prostate cancer cells and in chick chorioallantoic membrane (CAM) tumors. Here, DPYSL5 is linked to Familial prostate cancer.