TP53 and Familial prostate cancer: Genetic factors linked to high-risk prostate cancer and the development of NEPC include the loss of tumor suppressors RB1 and TP53, amplification of cell-cycle regulator Aurora Kinase A and MYCN, splicing of transcriptional repressor REST by SRRM4, increased expression of PEG10, and neural transcription factors, as well as prostate cancer cell lineage plasticity inducers BRN2 and ASCL15,7–16.