MMP2 and inflammatory bowel disease: C4M is a neo-epitope of MMP-2, -9, and -12 mediated degradation of the α1 chain of type IV collagen and has been studied as a biomarker in IBD where it mainly reflects a severely disrupted intestinal barrier, mucosal damage, endoscopic disease severity, and positively associates with non-response to biologics18,21–25.