Consistently, echinomycin-treated GPx2 KD tumour cells had significantly reduced levels of baseline oxygen consumption rate (OCR; OXPHOS) as well as of extracellular acidification rate (ECAR; glycolysis), relative to vehicle treated cells (Fig. 4g, h), further supporting pAMPK and GLUT1 as markers of dual metabolism. This evidence concerns the gene GPX2 and neoplasm.