HIF1A and neoplasm: Of note, suppression of metastasis and EMT hybrid states by echinomycin in PyMT1/GPx2KD tumours was recapitulated by GPx2 OE or induction in PyMT2 tumours (Figs. 2 and S3), thus reiterating a strong connection between GPx2 KD, HIF1α, partial EMT, and metastasis.