Subsequently, we analyzed the transcriptomic results of Celastrol treatment of RA, and found that the down-regulated genes mainly included TNF, FOS, ITGAM, CXCR4, HSP90AA1, PAX6, SPI1, PTGS2, ASCL1, GAD1, KCNA1, FOXG1, IRF4, LCK, EGR2, EOMES, SPP1, CCL3, BMP2, FLT3 and other targets. The gene discussed is PAX6; the disease is rheumatoid arthritis.