In addition, the main targets of immune and inflammatory factors that mediate RA are (IL2, JAK2, STAT1); The main genes that mediate the excessive activation of RA immune cells, the inflammatory hyperplasia of synovial tissue and the destruction of articular cartilage tissue are (MAPK1, MAPK14, MAPK8, MAP2K1, etc.)91,92. This evidence concerns the gene MAP2K1 and rheumatoid arthritis.