RA is characterized by synovial hyperplasia, production of cytokines, chemokines, and autoantibodies such as rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), osteoclast proliferation, angiogenesis, and systemic consequences such as cardiovascular, pulmonary, psychological, and skeletal diseases 28,29. This evidence concerns the gene PRTN3 and rheumatoid arthritis.