NFKB1 and rheumatoid arthritis: Moreover, these inflammatory factors regulate RA inflammation through signaling pathways such as JAK/STAT, NF-κB, and MAPK, leading to dysregulation of immune-inflammatory reactions, imbalance of dendritic cells, mast cells, natural killer cells, macrophages, Th1/Th2, and Th17/Treg ratios, and contributing to the progression and development of RA pathology 48–50.