The inflammatory targets that mediate rheumatoid arthritis mainly include (TNF, PTPN11, IL6, etc.); the main targets that mediate RA oxidative stress are NOS3; the targets that mediate the destruction of extracellular matrix tissue in RA mainly include (MMP9, MMP2, ANXA5, etc.). The gene discussed is ANXA5; the disease is rheumatoid arthritis.