Subsequently, we analyzed the transcriptomic results of Celastrol treatment of RA, and found that the down-regulated genes mainly included TNF, FOS, ITGAM, CXCR4, HSP90AA1, PAX6, SPI1, PTGS2, ASCL1, GAD1, KCNA1, FOXG1, IRF4, LCK, EGR2, EOMES, SPP1, CCL3, BMP2, FLT3 and other targets. This evidence concerns the gene PTGS2 and rheumatoid arthritis.