HPGDS, STAT1, PIK3R1, MMP2, MDM2, PPARA, MAP2K1, IL2, PTPN11, JAK2, IGF1R, KDR, GSK3B, ARIL6 and MAPK14 are potential key targets for Celastrol in the treatment of RA. This evidence concerns the gene PIK3R1 and rheumatoid arthritis.