According to the outcomes, GRP78 mRNA expression level was remarkably elevated in cisplatin-resistant NSCLC tissues (Fig. 6C), and Pearson’s correlation analysis revealed a remarkably positive link between GRP78 and PAK4 mRNA expression (r = 0.445, P < 0.05; Fig. 6D). This evidence concerns the gene HSPA5 and non-small cell lung carcinoma.