Similarly, although chronic stress and high GC levels are known to induce Tau pathology in the hippocampus and cortex, precipitating synaptic loss and behavioral impairment in animal models (i.e. anxiety, anhedonia, learning/memory deficits) [14, 15, 33], it is unclear whether or how stress/GCs stimulate the spreading of Tau pathology between these brain regions. Here, MAPT is linked to Anxiety.