In another study, combined paternal and maternal obesity was found to augment hypothalamus inflammation in the progeny, which might be behind a disturbed regulation of mechanisms controlling appetite (i.e., leptin signaling, Janus kinase/signal transducers and activators of transcription), thereby contributing to the onset of hyperphagia and obesity in the long term [35]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.