TP53 and neoplasm: Additionally, a frameshift deletion in TP53 (ENST00000269305:c.594delA) was observed at 28% VAF in the normal sample raising uncertainty as to whether this variant is germline or somatic (variant supported by 41 out of 90 paired reads in the tumour, and 6 out of 21 in the normal), a classification that is important for clinical reporting.