In order to investigate further the relationship between CHIP and TIN contamination, we scanned the sequencing data for the normal samples in the cohort of 168 AML patients for the presence of 168 point mutations previously reported in genes linked with CHIP and myeloid malignancies (IDH2, PRPF8, PPM1D, SRSF2, TP53, GNB1, ASXL1, GNAS, RUNX1, SF3B1, DNMT3A, MYD88, CCND3, TET2 and JAK2)15. The gene discussed is GNB1; the disease is acute myeloid leukemia.