NFIA and Global developmental delay: Gatad2b dosage-sensitive genes differentially expressed in multiple cell types include H3f3b, which has been previously shown to mediate neuronal fate specification through epigenetic transcriptional regulation [41] and to be associated with neuro-developmental delay, dysmorphic features, and brain abnormalities [42] and Nfia, which has been reported to control gliogenesis [43] and associated with brain malformations [44].