Transgenic animals (MIP-CreERT;Sox9-/-) displayed a trend towards glucose intolerance, with the 60 min time point reaching statistical significance (Fig. S1F, the respective area under the curve confirms the trend towards glucose intolerance in the knockout cohort), and isolated islets showed a stunted response to high glucose as evidenced by a smaller stimulation index (Fig. S1G, H). Here, SOX9 is linked to Glucose intolerance.