Multivariate analysis confirmed older age (for age ≥60 years; HR 2; p < 0.001) and the presence of JAK2 mutation (HR 1.4; p = 0.02) as independent risk factors for future arterial thrombosis, whereas the protective effect of cytoreduction was confirmed (HR 0.4; p = 0.04). Here, JAK2 is linked to Arterial thrombosis.