For the treatment of psoriasis, which represents the dermatological disease with the highest number of IB approvals, the following can be highlighted, among the drugs with anti-TNF action: infliximab (chimeric monoclonal antibody), etanercept (fusion protein), adalimumab (humanized monoclonal antibody) and certolizumab pegol (pegylated anti-TNF); those with anti-IL12/23 action (ustekinumab), anti-IL23 action (guselkumab, risankizumab), anti-IL17 (secukinumab, ixekizumab, bimekizumab) and anti-IL17 receptor action (brodalumab). The gene discussed is TNF; the disease is psoriasis.