As a consequence, the WNT signaling pathwayis activated to promote cell survival, proliferation, and differentiation.9 Since the WNT signaling is abnormally activatedin multiple cancers, several TANK1 inhibitors that can stabilize AXIN1and attenuate the WNT signaling have been developed for cancer treatmentin the past two decades.10,11 However, the safetyprofile of TANK1 inhibitors is still a question due to the observedon-target side effects, including intestinal toxicity12 and bone loss,13 and no TANK1inhibitor has been approved so far. Here, TNKS is linked to cancer.