MAPT and post-traumatic stress disorder: Similarly in one cross-sectional study tau accumulation in neocortical regions was higher in PTSD exposed groups and significantly associated with CI (Mohamed et al., 2019), whereas longitudinal follow-up data from the same cohort (Weiner et al., 2022) found no significant differences in tau accumulation between groups; the two studies used data of the same cohort which were older veterans with PTSD; but were different on study design (cross-sectional versus prospective cohort), making comparison of results difficult.