Markers associated with NASH progression, multidrug resistance–associated proteins 2 and 4 (MRP2 and MRP4), were elevated in NASH samples when normalized to extracellular signal-regulated kinase 2 (ERK2) (Fig. 1F), as described previously (19, 20, 21). The gene discussed is MAPK1; the disease is metabolic dysfunction-associated steatohepatitis.