Therefore, it was recommended by the panel of experts that patients with refractory CRS and asthma associated with elevated IgE (greater than 1000 ng/mL or 400 kUI/mL) and/or elevated Aspergillus fumigatus-specific IgE and/or IgG should be referred to an allergist/immunologist to investigate allergic bronchopulmonary aspergillosis. The gene discussed is IGHE; the disease is congenital rubella syndrome.