For anti-TNF-treatment, safety of perioperative treatment was addressed in patients with IBD undergoing abdominal surgery in a recently published prospective trial, the “Prospective Cohort of Ulcerative Colitis and Crohn’s Disease Patients Undergoing Surgery to Identify Risk Factors for Post-Operative Infection, the PUCCINI trial” [19]. The gene discussed is TNF; the disease is ulcerative colitis.