In agreement with the results from Cibersort, samples during infection had higher levels of expression for genes such as Maf, Icos (CD4 T cell activation), Cd69, FCGR3 (NK cell activation), Cd80, CD86 (macrophages M), as well as markers of cytotoxicity (GZMB, GZMK) and inflammation (IFNG, TNF) (Fig 3C and corresponding S5 Data). This evidence concerns the gene ICOS and infection.