CD4 and viral infectious disease: Consistent with our previous results from longitudinal data, the CibersortX analyses stratified by virus revealed that viral infections lead to significant (Padj <0.05, Mann–Whitney tests) increases of activated CD4 T cells (Fold-Changes for CoV: 1.8—and HRV: 1.76), activated NK cells (FC for Flu: 2.06, HRV: 2.44, CoV+HRV: 12.44), and Macrophages M1 (significant for all viruses except RSV, FC ranging between 3.79 -CoV- and 6.79 CoV+HRV).