Congruent genes that showed the highest levels of connections (per STRING) included GFAP, EGFR, TLR4, SNAP25, PTPRC, SLC6A1, CD44, and SNCA (Fig 2C) and it is possible these genes have a strong contribution to the GFAP mutation brain profile that mirrors AD. Here, SLC6A1 is linked to Alzheimer disease.