TLR4 and Alzheimer disease: From these models as well as the top two models (APP/PS1 and GFAP mutation), common up (N = 126) and down regulated genes (N = 42) with AD found in at least 9 models were identified and the most connected of these genes included TLR4, PTPRC, CD44, STAT3, TLR2, ITGB1, CXCR4, ITGB2, SPP1, FCGR2A, ANXA2, CSF1, and GFAP (Fig 4B).