From these models as well as the top two models (APP/PS1 and GFAP mutation), common up (N = 126) and down regulated genes (N = 42) with AD found in at least 9 models were identified and the most connected of these genes included TLR4, PTPRC, CD44, STAT3, TLR2, ITGB1, CXCR4, ITGB2, SPP1, FCGR2A, ANXA2, CSF1, and GFAP (Fig 4B). This evidence concerns the gene TLR2 and Alzheimer disease.