Meanwhile, Zhao et al. reported that in primary colon cancer cells, NSD2 silencing or knockout significantly downregulated H3K36me2, the expression of multiple oncogenes, and protein kinase B (AKT) activation, thereby inhibiting cell cycle progression, proliferation, migration, and invasion (Zhao et al. 2021). The gene discussed is AKT1; the disease is malignant colon neoplasm.