Using the murine 4T1 and D2A1 experimental models, supported by transcriptomic analyses, we show in this study that SCA1+ populations with CSC features can exist under 3 different conditions: (a) inherently to the tumor cell lines; (b) induced upon tumor cell exposure to Tu-Gr1+CD11b+ cells; and (c) selected from tumor cells following treatment with chemotherapy. Here, ITGAM is linked to neoplasm.