KLK3 and Familial prostate cancer: PSA screening policy and guidelines to date have been well established in the West, including the recommendation statement of screening for prostate cancer by the US Preventive Services Task Force [8], the National Comprehensive Cancer Network’s guidelines for Prostate Cancer Early Detection [9], European Association of Urology–European Association of Nuclear Medicine–European Society for Radiotherapy & Oncology–European Society of Urogenital Radiology–International Society of Geriatric Oncology Guidelines on Prostate Cancer [10].