CD274 and metastatic neoplasm: On multivariable analysis adjusted for all established prognostic factors (ECOG performance status, PD-L1 expression, organ sites of metastatic disease, DNLR, irAE development, and levels of hemoglobin, albumin, and LDH), developing an irAE remained independently associated with longer OS (hazard ratio, 0.53 [95% CI, 0.40-0.70]; P < .001).