Cho et al. showed that REV-ERB_ alpha, one of two Rev-Erb proteins in the nuclear receptor family of intracellular transcription factors which shows an important role in regulation of the core circadian clock by repression of the positive clock element Bmal, was associated with high triglyceride levels [41], and others [42] discovered that the danger of developing MetS is augmented in patients with NSV. The gene discussed is CLOCK; the disease is metabolic syndrome.