MAPT and diabetes mellitus: On the other hand, in the APswe/Psi1dE9/TauP301L mouse model, when exposed to a typical western diet to induce diabetes, microglia response to β-amyloid and Tau pathology was reduced, with a decreased phagocytic uptake and amyloid plaque clearance, along with less microglia located also in the vicinity of β-amyloid plaques in obese individuals with T2D than in those without T2D [103].