PDK2 and Hyperglycemia: Besides, hyperglycemia has been recently shown to induce an increase expression of pro-inflammatory lipocalin-2 (LCN2) in DRG SGCs, potentiating neuroinflammation and neurotoxicity via LCN2-pyruvate dehydrogenase kinase isoform 2 (PDK2)-lactic acid pathway contributing to the progression of DPN [146].