In this study, based on baseline peripheral blood lymphocyte subpopulations, biochemical indexes and blood routine tests, we utilize Lasso Cox regression to select eight predictive indicators [histologic subtypes, CD19+ B cells, NK cells, regulatory T cells, RBC, AST/ALT ratio (SLR), Apo B, and LDH] for disease progression prediction of R/M NPC patients treated with anti-PD-1 antibody. This evidence concerns the gene APOB and nasopharyngeal carcinoma.