While intratumoral CXCL10 was identified as a potential favorable prognostic factor in metastatic melanoma [19], circulating CXCL10 has also been reported to have dual effects and cell growth as well as angiogenesis in cancer, depending on CXCR3 expression and other factors in the TME [20]. The gene discussed is CXCL10; the disease is metastatic melanoma.