eNos loss contributed to APP amyloid formation processes and cognitive decline (Bergin et al., 2018), nNos played a vital role in synaptic plasticity and learning and memory (Paul & Ekambaram, 2011), while iNos could act as proinflammatory agents (Haj‐Mirzaian et al., 2016). This evidence concerns the gene NOS2 and Mental deterioration.