Administration of OT and OT analogues in differentrodent breastcancer models reduced breast tumors substantially (44–82%).107,115,137−139 For example, OT or atosiban (biased OTR ligand) was administeredvia osmotic pumps into xenograft models of BALB/c mice (n = 43) and Fisher rats (n = 22) bearing mammarycarcinomas TS/A and D-R3230AC, respectively, for 14 days.115 This resulted in up to 72% tumor reductionin animals treated with OT or atosiban compared to controls. The gene discussed is OXTR; the disease is neoplasm.