ME2 and Alzheimer disease: Note, however, that malate dehydrogenase, cytoplasmic (also known as malic enzyme 2, ME2) (Figure 1A, p = 0.004 by ANOVA), was S‐nitrosylated to an even greater degree in AD than control human brains, consistent with the notion that the alternative anaplerotic pathway access of malate or oxaloacetate into the TCA cycle may be regulated at this level by S‐nitrosylation (Figure 2A).