The molecularly defined renal carcinomas include TFE3-rearranged RCC, TFEB-altered RCC, ELOC-mutated RCC, FH-deficient and SDH-deficient RCC, ALK-rearranged RCC, and SMARCB1-deficient renal medullary carcinomas. This evidence concerns the gene SMARCB1 and renal carcinoma.