The molecularly defined renal carcinomas include TFE3-rearranged RCC, TFEB-altered RCC, ELOC-mutated RCC, FH-deficient and SDH-deficient RCC, ALK-rearranged RCC, and SMARCB1-deficient renal medullary carcinomas. The gene discussed is TFE3; the disease is renal carcinoma.