Despite that the peritrophic matrix (PM) does not act as a barrier for arbovirus infections, a peroxidase that mediates PM formation, enhance arbovirus infections through oxidative stress regulation (Talyuli et al., 2023), to infect the midgut epithelial cells (the first target of infection), the virus must first pass through the cellular mucin layer. This evidence concerns the gene MUC5AC and arbovirus infection.