One possible explanation for the significant reduction in SBP in BFRT group in the present study is that BFR training results in the production of large amounts of vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS), which in turn promotes vascular nitric oxide (NO) production and has a vasodilatory effect in the prevention and treatment of hypertension, which may reduce the incidence of CVD (Zhang et al., 2022). The gene discussed is VEGFA; the disease is hypertensive disorder.