Altered Cer levels are detected in several pathophysiological conditions including cancer (Brachtendorf et al., 2019), diabetes (Hammad et al., 2022; Hammad and Lopes-Virella, 2023), obesity (Raichur et al., 2019), Parkinson’s disease (Abbott et al., 2014), and other neurological disorders (Tomasello et al., 2022). The gene discussed is CBLN1; the disease is obesity due to melanocortin 4 receptor deficiency.