TNF and acute myeloid leukemia: FcγRI and FcγRIIa, the FcγRs that scaffold and internalize the h128-3/LILRB4 complex on monocytic AML cells, both have intracellular immunoreceptor tyrosine-based activating motifs (ITAM) that canonically drive the expression and release of pro-inflammatory cytokines and chemokines (e.g. TNF, IL-1β and IL-8) that alter the effector function, migration and survival of leukocytes [17, 36].