FcγRI clearly plays a significant role in the h128-3-induced internalization of LILRB4 on FcγRhigh monocytic AML THP-1 cells, but we could not rule out the possibility that FcγRIIa can also bind the h128-3 Fc and internalize the h128-3/LILRB4 complex. This evidence concerns the gene LILRB4 and acute myeloid leukemia.