The estimated prevalence of dysferlinopathies varies according to the region, with a high prevalence in endogamous populations, such as populations in Maghreb, Israel, Saudi Arabia, and Iran in Jewish people from Libya and from the Caucasus and in some regions of Brazil, where the subtype of LGMD2R dysferlin-related is the most common [9-12]. The gene discussed is DYSF; the disease is neuromuscular disease caused by qualitative or quantitative defects of dysferlin.