Increasing evidence shows that after brain trauma, Angpt1 functions dually in promoting angiogenesis and neurogenesis to enhance BBB integrity and neurological regeneration (Meng et al., 2014; Michinaga and Koyama, 2019; Wang et al., 2019) in addition to its indispensable roles in the developmental cardiovascular formation and the maintenance of adult vascular stability. Here, ANGPT1 is linked to brain injury.