AKT1 and ischemia: In an in vitro model of ischemia using mouse organotypic hippocampal slice cultures exposed to oxygen-glucose deprivation (OGD), Sun et al. show that both Insulin and Insulin-like growth factor dose-dependently reduces OGD-induced neuronal injury and Insulin-induced neuroprotection involves the PI3K/Akt pathway (Sun et al., 2010).